We are proud to base all of our custom-compounded supplements based on the best scientific literature. Knowing what really works and how much is needed to get the results you want is what makes these products so effective.
If you love information, data and science like we do, read on for some of what we used in creating this unique formulation.
Efficacy of CoQ10 as supplementation for migraine: A meta‐analysis
Neurologica scandinavia Volume139, Issue3 March 2019: 284-293
Effect of coenzyme Q10 supplementation on clinical features of migraine: a systematic review and dose–response meta-analysis of randomized controlled trials
Mohammad Parohan, Payam Sarraf, Mohammad Hassan Javanbakht, Sakineh Ranji-Burachaloo & Mahmoud Djalali (2020) Effect of coenzyme Q10 supplementation on clinical features of migraine: a systematic review and dose–response meta-analysis of randomized controlled trials, Nutritional Neuroscience, 23:11, 868-875, DOI: 10.1080/1028415X.2019.1572940
Open label trial of coenzyme Q10 as a migraine preventive
Cephalalgia 2002 Mar;22(2):137-41. doi: 10.1046/j.1468-2982.2002.00335.x.
Efficacy of coenzyme Q10 in migraine prophylaxis: A randomized controlled trial
Neurology Feb 2005, 64 (4) 713-715; DOI: 10.1212/01.WNL.0000151975.03598.ED
Improvement of migraine symptoms with a proprietary supplement containing riboflavin, magnesium and Q10: a randomized, placebo-controlled, double-blind, multicenter trial
J Headache Pain. 2015; 16: 32. Published online 2015 Apr 3. doi: 10.1186/s10194-015-0516-6
Effectiveness of high-dose riboflavin in migraine prophylaxis. A randomized controlled trial
Neurology 1998 Feb;50(2):466-70. doi: 10.1212/wnl.50.2.466.
High-dose riboflavin treatment is efficacious in migraine prophylaxis: an open study in a tertiary care centre
Eur J Neurol: 2004 Jul;11(7):475-7. doi: 10.1111/j.1468-1331.2004.00813.x.
Medium-dose riboflavin as a prophylactic agent in children with migraine: a preliminary placebo-controlled, randomised, double-blind, cross-over trial
Cephalalgia 2010 Dec;30(12):1426-34.
Prophylaxis of migraine headaches with riboflavin: A systematic review
J. Clin Pharm and Therapeutics:Volume42, Issue4, August 2017 p394-403
A combination of riboflavin, magnesium, and feverfew for migraine prophylaxis: a randomized trial
Headache 2004 Oct;44(9):885-90. doi: 10.1111/j.1526-4610.2004.04170.x.
Feverfew (Tanacetum parthenium L.): A systematic review
Pharmacogn Rev. 2011 Jan-Jun; 5(9): 103–110.
Feverfew for preventing migraine
Wider B, Pittler MH, Ernst E. Feverfew for preventing migraine. Cochrane Database of Systematic Reviews 2015, Issue 4. Art. No.: CD002286. DOI: 10.1002/14651858.CD002286.pub3.
An observational study of fixed-dose Tanacetum parthenium nutraceutical preparation for prophylaxis of pediatric headache
Moscano, F., Guiducci, M., Maltoni, L. et al. An observational study of fixed-dose Tanacetum parthenium nutraceutical preparation for prophylaxis of pediatric headache. Ital J Pediatr 45, 36 (2019). https://doi.org/10.1186/s13052-019-0624-z
Comparison between the efficacy of ginger and sumatriptan in the ablative treatment of the common migraine
Phytother Res 2014 Mar;28(3):412-5. doi: 10.1002/ptr.4996. Epub 2013 May 9.
Double-blind placebo-controlled randomized clinical trial of ginger (Zingiber officinale Rosc.) addition in migraine acute treatment.
Cephalalgia, 39(1), 68–76. https://doi.org/10.1177/0333102418776016
Double-blind placebo-controlled randomized clinical trial of ginger (Zingiber officinale Rosc.) in the prophylactic treatment of migraine.
Cephalalgia, 40(1), 88–95. https://doi.org/10.1177/0333102419869319
Vitamin Supplementation as Possible Prophylactic Treatment against Migraine with Aura and Menstrual Migraine
Biomed Res Int. 2015; 2015: 469529.
The effect of vitamin E on the treatment of menstrual migraine
Sci Monit: 2009 Jan;15(1):CR16-9.