Probiotics are not all created equal.  Here, we will share some of the general research on probiotic supplementation as well as specific key studies that we reviewed to include these specific probiotic strains in our formulation.  Read the labels carefully when comparing products and find those, like ours, that contain the proven, effective probiotic contents!

Here are a few of the studies we reviewed:

Intestinal microbiota in human health and disease: the impact of probiotics.

Beneficial Microbes: The pharmacy in the gut.

Molecular Players Involved in the Interaction Between Beneficial Bacteria and the Immune System

The Scientific Basis for Probiotic Strains of Lactobacillus

Lactobacillus reuteri (the most researched probiotic):

Role of Lactobacillus reuteri in Human Health and Diseases

Oral Supplementation With Probiotic L. reuteri NCIMB 30242 Increases Mean Circulating 25-Hydroxyvitamin D: A Post Hoc Analysis of a Randomized Controlled Trial

Cholesterol lowering and inhibition of sterol absorption by Lactobacillus reuteriNCIMB 30242: a randomized controlled trial

The effect of Lactobacillus reuteri supplementation in adults with chronic functional constipation: a randomized, double-blind, placebo-controlled trial.

Lactobacillus reuteri good for health, Swedish study finds

Probiotic Lactobacillus reuteri promotes TNF-induced apoptosis in human myeloid leukemia-derived cells by modulation of NF-kappaB and MAPK signalling.

Histamine derived from probiotic Lactobacillus reuteri suppresses TNF via modulation of PKA and ERK signaling.

Growth inhibition of oral mutans streptococci and candida by commercial probiotic lactobacilli–an in vitro study.

Selective probiotic bacteria induce IL-10-producing regulatory T cells in vitro by modulating dendritic cell function through dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin

Lactobacillus reuteri induces intestinal immune tolerance against food allergy in mice

Lactobacillus species, including acidophilus:

A double-blind placebo-controlled study of the effects of Lactobacillus acidophilus on plasma lipids.

Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors

Assimilation of Cholesterol by Lactobacillus acidophilus

The Scientific Basis of Lactobacillus acidophilus NCFM Functionality as a Probiotic

Dose–Response Efficacy of a Proprietary Probiotic Formula of Lactobacillus acidophilus CL1285 and Lactobacillus caseiLBC80R for Antibiotic-Associated Diarrhea and Clostridium difficile-Associated Diarrhea Prophylaxis in Adult Patients

Lactobacillus acidophilus LA 1 binds to cultured human intestinal cell lines and inhibits cell attachment and cell invasion by enterovirulent bacteria.

Bifidobacterium species:

Bifidobacteria and Their Role as Members of the Human Gut Microbiota

Meta-analysis of the effects of Bifidobacterium preparations for the prevention and treatment of pediatric antibiotic-associated diarrhea in China

Omics of bifidobacteria: research and insights into their health-promoting activities.

Bifidobacteria as probiotic agents – Physiological effects and clinical benefits

Diet and chronic constipation. Benefits of oral supplementation with symbiotic zir fos (Bifidobacterium longum W11 + FOS Actilight)

Effects of Bifidobacterium longum BB536 administration on influenza infection, influenza vaccine antibody titer, and cell-mediated immunity in the elderly.

Synbiotic therapy (Bifidobacterium longum/Synergy 1) initiates resolution of inflammation in patients with active ulcerative colitis: a randomised controlled pilot trial

Double-blind, randomised, placebo-controlled intervention trial to evaluate the effects of Bifidobacterium longum CECT 7347 in children with newly diagnosed coeliac disease.

Efficacy of probiotic treatment with Bifidobacterium longum 536 for induction of remission in active ulcerative colitis: A randomized, double-blinded, placebo-controlled multicenter trial.